Entrapro

Entrapro Entrapro is an 100% Australian Owned Company specialising in Probiotics, Prebiotics (Synbiotics) and wellness supplements to keep you at your best.

08/01/2022

Should I take prebiotics at the same time as probiotics?

Prebiotics can provide a significant boost to the levels of probiotics if they are taken in sufficient quantities. However, prebiotics alone, being FODMAPs, can cause digestive problems if they are feeding bad bugs in people with significant dysbiosis. It is essential to pair the prebiotics with probiotics that are both effective against pathogens and in high enough numbers to be effective. Many probiotics on the market have been found to stimulate bad bugs instead of suppressing them!

08/01/2022

Do probiotics cause parasite expulsion?

No, not totally, and need high levels just to reduce symptoms that are caused by them. In my experience, if our synbiotic product doesn’t work wonders with bloating and diarrhoea, then protozoan parasites are often the reason. I then recommend that clients speak to their doctors regarding treatment with a combination of antibiotics. The antibiotics do often, subsequently, cause problems by doing collateral damage to the bacteria in the gut but then our product is effective against the bacterial dysbiosis that this treatment causes. Antibiotics are not always successful in the removal of parasites but are more effective than herbal remedies, which tend to suppress, rather than remove parasites.

08/01/2022

Does taking probiotics daily help your overall health? Are there any studies that looked into this question?

I wouldn’t normally share a thing like this but here is an extract from an email sent to me this week. You can decide what my answer is to your question.

“Dear John and Lyn

Thank you for helping me understand better the importance of caring for my microbiome, in a way I was easily able to understand.

I believe the suggestion to get away from gluten and dairy has had a huge effect on how my body reacts to these foods but the greatest change to my health, in my opinion, has been from using your probiotics.

My gastroenterologist had me on just about every appropriate drug available to try and slow down my aggressive flare up of Crohn's Disease. None of these drugs slowed down the progression of the disease.

I have had 4 bowel resections and 1 intensive bowel repair due to a perforation of the bowel which led to sepsis and near death. The last resection being in 2003.

The disease flared severely again around 2008-2009. For 2-3 years my gastroenterologist tried in vain to slow down the progression and aggression of the disease but unfortunately it was in vain. She was quite disappointed for me and needless to say for the work she does in this area, that nothing she had tried had made any difference, no slow down, not even a slight change, the disease was progressing regardless.

Colonoscopy's were performed every 12 months as a matter of course. With drug therapies, I had the severe reactions, at time suffering neurological side effects.

In 2011 after a colonoscopy, my gastroenterologist was so very disappointed to inform me the tests weren’t good and we’d be heading back to surgery in the not too distant future. With that being said, she proceeded to instruct me that she was putting me back on a particularly strong and very expensive drug, however I needed to be off all other medications she had me on for at least 3 weeks. She wrote me out a prescription with a schedule for the drug dosage and charges for 3 months until seeing her again.

3 days after seeing my doctor and receiving this disappointing news, John, you had spoken to me (not knowing at that time about my recent test results). You asked me if I would take your probiotics to give my “poor old bowel” the best way to get some healthy gut flora to give it a bit of a fighting chance against this wretched disease. You said outright that the probiotics won’t heal the disease, but will aid my gut microbiome to have healthier flora to fight off the overload of bad bugs ( my layman’s terms, sorry).

I had to be off all meds for a minimum of 3 weeks. I knew your kind offer of using your probiotics might be my only drug free window, to see if and what effect the probiotics might have.

Seriously, taking your suggestion was like a miracle had been given to us, the change was immediate for me and just blew our minds. My family and I had lived on a knife edge - literally. We tried to live as best we could “around” this disease. My first bowel resection happened when I was 26 years old and 5 months pregnant. I was hospitalised for 1 1/2 months prior to surgery. Back in the 80’s they couldn’t perform X-rays if you were pregnant. Out of options, exploratory surgery found I had Crohn’s disease and needless to say, a blocked bowel and looping.

This was the continuing story of my life. That was until 2011 when I was introduced to your probiotics and taking in the dietary changes suggested due to the damage in my bowel. The great news was and still is, from the day I started taking the probiotics, the chronic Diarrhoea I lived with for over 35 years had stopped. I was finally able to tell what foods disagreed with me.

The clincher is, if I forgot to take the probiotics, regardless of how well I managed my diet, the diarrhoea returned. A valuable lesson learned :)

The dilemma I had was telling my specialist that I hadn’t started her drug therapy after the suggested three weeks break from all medications she had previously prescribed. I was 3 months into the probiotics, no drugs and had never felt so good in all my life and due for my 3 monthly specialist visit.

I was truly concerned my specialist would say she was unable to treat me as her patient (hospital specialist protocol).

Instead, when I told her about the diet and probiotics, she said she was happy to support me and do 6 monthly colonoscopy’s to monitor my progress.

After 6 months from prior colonoscopy, she performed another and was so pleasantly surprised to find the disease had NOT progressed. She told me to continue doing what I was doing and we would do another colonoscopy in 6 months.

That colonoscopy showed clearly the inflammation had settled and the ulceration had reduced in size and number. She followed through with 6monthly colonoscopy’s for 2 years, then reduced down to 1 year. She could barely see any sign of the disease so suggested leaving it for two years for the next colonoscopy but always letting me know to call her immediately if there was a change. With that colonoscopy she couldn’t see any Crohn’s.

Here it is, 2019 and I have NO return or any sign of the disease.

I have had to have stoma surgery done, not because of a Crohn's flare but because of MND/ALS. This disease has caused an inability to get to the bathroom quickly due to my legs no longer working and a very short bowel causing urgency- as a result of too much bowel being removed due to the Chohn’s flares- which I now know can be avoided.

My Colorectal surgeon said he was surprised to find my bowel was very healthy. My gastroenterologist was working with him doing the surgery and said there was no sign of the disease.

I was prewarned that Crohn's patients have a very high percentage rate of a flare up after stoma surgery. Well, it’s been two years since my stoma surgery. I have had also had the stoma resighted a year ago and there’s no flare up nor tenderness to indicate the Crohn’s starting to flare again.

I would definitely say the 8 1/2 years of being drug free and experiencing the reversal from chronically bad to incredibly great gut health is an amazing and awesome testament to your probiotics that in my heart I know work.

With gratitude that goes beyond words.

Sincerest thanks

Shirley Bossard

08/01/2022

How can you determine a quality probiotic supplement, with latest scientific studies showing that individuals on probiotics showing no matching evidence their body has sustained these cultures?

It is an enduring myth that probiotics replace the good cultures that have been wiped out by antibiotics; that is not the way they work! The good bacteria that we have lost were not probiotics and you can’t replace them with probiotics! Let’s start with a breast-fed baby…. Breast milk contains lactoferrin, which chelates iron and makes it non-available for the gut bacteria. Probiotics don’t need iron so they have an advantage in that situation and predominate in the baby’s gut. However, once breast milk is no longer available, the iron-requiring bacteria, that predominate in the adult gut, take over and probiotics drop to, perhaps 1–2% of the population, at which level they can’t do much. Also, during those early months and years, the immune system has “training wheels” on and is learning which bacteria to support and which to kick out. It makes the entirely reasonable assumption that the bacteria picked up from Mum are likely to be mostly good ones, so it protects those. This is why one can recover from a Salmonella infection. This means that any probiotics that were not part of the original set will also be kicked out. This is why faecal matter transplants often fail, particularly when the donor’s spectrum of bacteria is very different from the recipient’s original set. Thus, with probiotics, they really only work WHILE THEY ARE PASSING THROUGH. Although it is an advantage if they adhere to mucosal cells, those that do will still be washed out over time. The answer, therefore, is to consume synbiotics (combinations of pro- and prebiotics), preferably in powder form (because there is not enough room in a capsule for significant amounts of prebiotics and because the probiotic cells rehydrate prior to consumption and thus don’t need to suck in stomach acid or intestinal bile). The strains also need to be the best possible at inhibition pathogens and be in high enough initial numbers and be boosted by around 50–200 fold by the prebiotics in order to create ideal conditions and suppress the bad bacteria, while they are passing through. ONLY THEN CAN YOU ACHIEVE AMAZING RESULTS.

08/01/2022

How do you make beneficial probiotics?

A century ago, before antibiotics devestated our collective gut microbiomes, fermented foods may well have contained enough good bacteria to provide some benefit. These days things are different for a growing proportion of the population. Many individuals require more than fermented foods can provide. This is often because the cultures in fermented foods have varying degrees of efficacy. This is reflected in the great variation in efficacy seen in strains tested by the NSW Department of Primary Industries. Out of 49 strains that had been supplied by commercial probiotic suppliers and which, presumably, represent cultures isolated originally from fermented foods, only a handful showed any significant suppression of the growth rate of E. coli, and about a third actually stimulated the bad bug, with most being in between. And suprisingly, there was a great deal of variation between strains of the same species (eg L. acidophilus). So the bottom line is one needs to have access to basic research which indicates which strains to use and which to avoid. And you can’t tell by looking at the label. However, it is a good idea to avoid products that contain a whole lot of different species because that is a sure indication that the manufacturer doesn’t know what they are doing.

08/01/2022

I’m lactose intolerant and wondering if using lactase enzyme tablets to eat dairy, would there be any long term bad effects from the dairy?

Are you sure your problem lies with the lactose? Many people who label themselves “lactose intolerant” may have leaky gut from dysbiosis and may then have dairy protein intolerance as the casein molecules translocate into their bloodstream and provoke a response from their immune system. Having said that, if you truly do have a problem with lactose, then lactase enzyme tablets should help and there should be no long-term bad effects from the dairy. Remember that cheese doesn’t have much lactose in it and the traces that are there wouldn’t be enough to affect a truly lactose intolerant person. If you react badly to cheese you are probably dairy protein intolerant and may benefit from taking a good synbiotic like Entralive Maximal.

08/01/2022

How can you add good bacteria to your gut flora after a course of antibiotics?

As a microbiologist dealing with people’s gut problems, which are usually brought on by the destruction of large segments of their gut microbiome, I can tell you that it is very difficult to replace the bacterial species that you have lost due to antibiotics. It is a myth that they can be replaced with probiotics (even the best brands) because the ones you have lost are not probiotics and because your immune system imprinted itself on your original set of bacteria that you got from Mum and your early environment and will kick out any “foreigners”, even if they are beneficial probiotic bacteria. This is why one can recover from a Salmonella infection, for example and why faecal enemas fail when the donor’s spectrum of species is very different to the recipients original set. In such cases, the only thing one can do is to take a very good synbiotic containing the best strains, boosted up the equivalent of taking trillions of probiotic cells with appropriate prebiotics (fibre ingredients) and continuing to take them every day to recreate “ideal” conditions in your bowel. I was given metronidazole to eliminate a Giardia infection about 20 years ago. It left me with IBS (diarrhoea form) due, presumably, to the elimination of many species of “good” bacteria in my gut. I take Entralive Maximal every day and it controls the problem. Diet can only work via the particular bacteria in your gut and if there are many more bad ones than good ones, then even a good diet will not normalise gut function, though I agree that it will favour the good ones, assuming they are there. I see many people who cannot even tolerate a good diet and Entralive is the only thing that works for them. Even then, they have to start low and work up to a decent dose because they can have severe adaptation issues. Most probiotics on the market don’t do much, for various reasons but the science is improving rapidly.

08/01/2022

Given that intestinal flora seem to have an influence on personality, why aren’t probiotics being sold which are made from the gut bacteria of particularly well-adjusted people?

A very good question! But the "good” bacteria in peoples’ intestines are not probiotics and thus do not have GRAS status and cannot, by law, be sold. A specialist doctor may be able to prescribe or administer them but then they wouldn't be available for him anyway: Catch 22!

08/01/2022

How can I improve the health of my microbiome?

There is a large elephant lurking in this room and it is the problem that diet can only operate on the bacteria that are in a person's gut. If the individual has had a poor diet for a long period, the population of bugs will be skewed towards ones that have an advantage whilst feeding on that diet. If there are "good” bacteria present, a good diet, with plenty of fibre, etc, will select for the good ones and they will increase. However, if that person either inherited a poor microbiome or has had a lot of antibiotics, there may not be enough different species of good bacteria to feed up and the good diet may just feed the bad ones. In extreme cases, individuals like this may need a faecal matter transplant (FMT), but even then, many reject the donor species if their immune systems do not recognise them as being part of the original set they had as babies. In such a case one needs to take a good synbiotic and to keep on taking it to recreate ideal conditions in the gut.

08/01/2022

Do you take probiotics and do they help you?

Yes, I do and yes, they do. I had a protozoan parasite (Giardia) and was treated with metronidizole (flagyl), about 20 years ago. It got rid of the parasite, but left me with diarrhoea, because it did collateral damage to my gut microbiome. Because I was in charge of research at a company that manufactured cultures for the dairy industry and because I was involved in a government-funded Cooperative Research Centre, based at UNSW, I was able to develop a synbiotic product (=probiotics + prebiotics) which has been highly effective at controlling my IBS. The ability of a probiotic product to be effective is related to many factors and all the boxes need to be ticked to get the desired result.

08/01/2022

Will probiotic in capsule form really work or its just fake. And will taking capsule of lactobacillus rhamnosus +lactobacillus retueri will survive theough my digestive system, because iam taking capsules of these two bacteria strain?

Not so much “fake” as “not as good as a powder with added prebiotics”. In the latter case, the bacteria rehydrate before they get to the stomach acid and don’t need to suck in acid or bile, so the survival rate is higher. Also, the prebiotics boost numbers many fold as they travel down the GIT.

08/01/2022

If prebiotics and diet affect the microbiome, why should we take a probiotic?

Extensive use of antibiotics has depleted the average microbiome to such an extent that many people now have very few species of good bacteria upon which a good diet can operate. In fact, many now have a bad reaction to FODMAPs (many of which are prebiotics - FOS and inulin for example), which ordinarily will stimulate the good bacteria. FODMAPs stands for Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols. This is because there is an excess of bad bacteria left to feed on the prebiotics, disaccharides, monosaccharides and polyols. Such individuals therefore need to consume high levels of probiotics in order to suppress the bad bacteria and reproduce something approaching ideal conditions in their gut. Individuals with susceptibility to FODMAPs will often experience an adaptation period when taking a synbiotic (a combination of pro- and prebiotics) but can potentially benefit once they get through that period because only a synbiotic has the potential to deliver very high levels of probiotics to the gut.

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